Excretion and metabolism of catecholamines by the isolated perfused rat kidney.

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Excretion and metabolism of catecholamines by the isolated perfused rat kidney.

The excretion and metabolism of labeled epinephrine and norepinephrine by the isolated, perfused rat kidney were studied. The excretion of both catecholamines significantly exceeded the amount filtered, thus providing direct evidence of net tubular secretion. Renal clearance of epinephrine was significantly greater than that of norepinephrine. Tubular secretion was a linear function of the conc...

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ژورنال

عنوان ژورنال: Journal of Clinical Investigation

سال: 1979

ISSN: 0021-9738

DOI: 10.1172/jci109533